张大同

发布时间:2014-10-17作者:出处:化学与制药工程学院责任编辑:张大同

姓 名

张大同

性 别

出生年月

1973.04

学 历

博士

毕业时间

2006.06

专 业

药物化学、有机化学

电 话

13708925788

邮 编

250353

E-MAIL

datong_zhang@163.com

单 位

化学与制药工程学院

通讯地址

济南市长清区大学路3501号 半岛电竞app化工学院

个人简历:

1991.9-1995.7,山东医科大学 药学专业 本科;

1995.9-1998.7,山东医科大学 药物化学专业 硕士;

2003.09-2006.7,山东大学 有机化学专业 博士;

2006.7至今,半岛电竞app化学与制药工程学院任教。制药工程与药物制剂系教授,硕士研究生导师。

2012.7-2013.1,美国Virginia Commonwealth University 访问学者

研究领域:

药物化学、有机分子荧光探针。

奖励和荣誉:

2007年指导的论文被评为“校级优秀本科毕业论文”

2008年指导的论文被评为“校级优秀本科毕业论文”

2009年指导的论文被评为“校级优秀本科毕业论文”

2012年指导的论文被评为“校级优秀本科毕业论文”

2008年指导的论文被评为2009年“山东省优秀学士学位论文”

2011年被评为山东轻工业学院优秀教师.

2014年 “有机废弃物发酵和可燃气体输送发电监控关键技术研究”获山东省科技进步二等奖(第三名)

发表文章:
1.Xiao-Bo Wang, Xue Hao,Datong Zhang*,Yan Jiang. Reaction-based Fluorescent Turn-on Probe for Selective Detection of Thiophenols in Aqueous Solution and Living Cell. Dyes and Pigments, 2017, 142, 167-174 .
2. Xiao-Bo Wang,
Datong Zhang*.A novel reaction-based fluorescent turn-on probe for biothiols and its application in cell imaging.Sensors and Actuators B: Chemical, 241 (2017) 327–334.
3. Xiao-Bo Wang, Jianhua Zhou,Datong Zhang*and Bin Wang. A very fast 3-hydroxy-coumarin-based fluorescent probe for highly selective and sensitive detection of thiophenols and its application in water samples. Anal. Methods, 2016, 8, 6916–6922.
4. Ruibing An, Peng Wei,Datong Zhang*, Na Su.A highly selective 7-hydroxy-3-methyl-benzoxazinone based fluorescent probe for instant detection of thiophenols in environmental samples. Tetrahedron Letters, 2016, 57, 3039-3042.
5.Ruibing An,Datong Zhang,*, Yan Chen, Yue-zhi Cui.A “turn-on” fluorescent and colorimetric sensor for selective
detection of Cu2+ in aqueous media and living cells.Sensors and Actuators B: Chemical, 222 (2016) 48–54.
6. Peng Wei,Datong Zhang*, Zhigang Gao, Wenqing Cai, Weiren Xu, Lida Tang, GuilongZhao*. Iodine Monochloride(ICl) as a Highly Efficient, Green Oxidant for the Oxidation of Alcohols to CorrespondingCarbonyl Compounds.SyntheticCommun.,
2015, 45(12):1457-1470.
7.
Datong Zhang*, Yuntong Ma, Ruibing An. New colorimetric chemosensor based on rhodamine hydrazide to detect Cu2+ ions by naked eye.Res Chem Intermed., 2015, 41(8): 5059-5069.
8.
Gao Zhigang,ZhangDatong*, Wei Peng, Wang Zhe, Xie Yafei, Liu Yuqiang, Xu Weiren, Tang Lida, Zhao Guilong*. A facile convergent synthetic procedure for 3-deoxydapagliflozin as SGLT2 inhibitor. Chin. J. Org. Chem, 2014, 34, 1829-1939..
9.
Datong Zhang, Yuntong Ma, Yu Liu and Zhao-Peng Liu. Synthesis of sulfonylhydrazone- and acylhydrazone- substituted 8-ethoxy-3-nitro-2H-chromenes as potent antiproliferative and apoptosis inducing agents. Arch. Pharm. Life Sci. 2014, 347, 576-588.

10
.Datong Zhang*, Lingyan Huo, Laichun Lu, Qiong Yu, Jianwu Wang, Yanyan Yang. Synthesis and preliminary antibacterial evaluation of hydroxamic acid and N-formyl hydroxylamine derivatives bearing oxazole ring. Medicinal Chemistry Research, 2013, 22(3):1426-1437.
11.
Datong Zhang*, Guangtian Wang, Guilong Zhao,Weiren Xu, Lingyan Huo. Synthesis and Cytotoxic Activity of Novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives .European Journal of Medicinal Chemistry, 2011,46 (12):5868-5877.
12.
Datong Zhang*, Guangtian Wang, Chubing Tan*, Weiren Xu, Yuan Pei and Lingyan Huo. Synthesis and biological evaluation of 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid derivatives.Archives of Pharmacal research, 2011, 34(3):343-355.
13.Datong Zhang*, Jiong Jia, Lijuan Meng, Weiren Xu, Lida Tang, and Jianwu Wang.Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate-based Hydroxamate Derivatives Containing Isoxazole Rings.Archives of Pharmacal research, 2010, 33(6):831-842.
14.Datong Zhang, Zongheng Wang, Weiren Xu, Fanggang Sun, and Jianwu Wang. Design,Synthesis and Antibacterial Activity of Novel Actinonin Derivatives Containing Benzimidazole Heterocycles.European Journal of Medicinal Chemistry, 2009,44 (5),2202-2210

目前承担和参与项目:
先后主持和参与了山东省自然科学基金、山东省中青年科学家奖励基金和济南市高校院所自主创新计划,并承担多项企事业单位横向课题。

社会兼职:中国化学会会员。现为Bioorganic & medicinal chemistry letter、European journal of medicinal chemistry、Journal of heterocyclic chemistry, Medicinal Chemistry Research等期刊审稿专家。

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